A judicial source was quoted as saying that an attacker blew himself up in a corridor after the security forces prevented him from entering the building.
SANA quoted a source at the Damascus Police Command as saying that a terrorist wearing an explosive belt blew himself up in the building.
According to the Beirut-based al-Mayadeen television, the security forces have surrounded the scene of the incident.
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Shortly after the court house bombing, the Syrian capital was hit by a second bomb attack in an area to the west of the building.
The second attack occurred as a bomber detonated an explosive device inside a restaurant in the al-Rabweh area, state media reported, adding that there were several casualties.
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No group has immediately claimed responsibility for the attacks.
The blasts come a few days after an explosion targeted the Syrian capital.
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On March 11, at least 46 people, most of them Iraqis, were killed in two bomb explosions near the Bab al-Saghir cemetery in the Bab Masala area of Damascus in one of the bloodiest attacks in the city.
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Tahrir al-Sham, which includes the former al-Qaeda branch in Syria, Jabhat Fateh al-Sham, claimed responsibility for the twin bombings.
